Aging is Treatable
While aging is a normal continuation of organismal growth and maturity, it may also be viewed as a summation of age-related diseases, and as a disease itself. The paradigm on aging is evolving: what was once assumed to be normal and inevitable, is now perceived as disease and alterable. We can treat aging and delay the onset of age-related disease, prolong healthful life, and lessen the burdens of infirmity and frailty seen in the elderly. While the language (and the hype) of longevity medicine centers on lifespan prolongation, the more important goal should be the extension of healthspan.
At Lowcountry Male, we have reviewed the latest research to develop a systematic plan to achieve and
regain youthful vigor and vitality.
Our program works through four different pathways:
• Improving immune function through thymic and immune regeneration
• Slowing cell senescence (aging) through TOR inhibition
• Eliminating senescent cells through senolytics
• Improved immune function via thymic gland recovery
These therapies can be done individually or combined to form the ultimate anti-aging regimen. They can also be safely added on to one of our hormone replacement programs for added
I. THYMIC REJUVENATION
The thymus is a gland which produces T cells which play a central role in immune response. After puberty, most functional thymic tissue is replaced by adipose tissue. As we age, the decline in immune function makes us vulnerable to infection and disease, as well as cancer and the ravages of aging in general.
The goal of thymic rejuvenation is to prevent or reverse the signs of gradual immune deterioration that occurs with age.
A clinical trial known as the TRIIM study (Thymic Regeneration, Immunorestoration and Insulin Mitigation), reveals a pathway for restoring thymic function and possibly slowing or reversing aging. In the study, researchers used a protocol intended to regenerate the thymus with the use of hGH, metformin, and DHEA. The results showed participants shed 2 years off their biological age according to the GrimAge predictor model (a method of analyzing a subject’s DNA to track a person’s biological age vs their chronological age). In addition, MRI studies revealed highly significant evidence of thymic regeneration, with restoration of functional thymic mass. Furthermore, favorable changes in immune cell proliferation of previously exhausted cells was demonstrated. Underactive immune systems, especially in older people, leave them at risk for age-related diseases, especially infections and cancers.
With our Thymic Rejuvenation protocol, you can expect:
• Increased cellular repair and recovery
• Improved immune function
• Increased muscle mass
• Decreased body fat
• Decreased inflammation
• Fuller and healthier hair
• Improved skin and collagen
• Improved vitality and energy
• Improved sleep
Our Thymic Rejuvenation Package is built around CJC/Ipamorelin (a peptide or short chain of amino acids) and metformin (a drug which optimizes cellular insulin sensitivity)
CJC/Ipamorelin is a peptide which increases the production and stimulates the release of growth hormone. After maturation at around age 20, our levels of growth hormone steadily decline as we age. We use CJC/Ipamorelin to increase growth hormone (GH) levels and it is the increased GH levels primarily responsible for the thymic recovery seen in the TRIIM trial. In addition, it has the benefit of enhancing muscle growth and recovery, as well as fat loss.
Metformin is a drug which improves insulin sensitivity. It has typically been used as a 1st line treatment in type 2 diabetes and in pre-diabetes to prevent or slow progression to clinical diabetes. It has been around a long time and has an excellent safety profile. Metformin increased the levels of a cell enzyme called AMPK, whose benefit is to signal cells to consume stored fat and promote weight loss. Strong evidence suggests that metformin, through its protective effects and AMPK-activating properties, can help prevent cancer, cardiovascular disease, obesity and its consequences, and even neurodegenerative disorders.
Our physician supervised program includes CJC/Ipamorelin, metformin, and a custom combination of supplements for added synergy.
II. RAPAMYCIN TOR INHIBITION
mTOR is a cellular protein which regulates and drives cellular growth and aging. In our developmental years, high TOR is beneficial and vital. In maturation, high TOR is detrimental. Increased levels of TOR lead to the production of senescent cells. Cellular senescence is the irreversible arrest of healthy cellular proliferation and resistance to programmed cell death, a sort of “zombie” state with profound effects. Senescent cells are metabolically altered, dysfunctional, and proinflammatory. The accumulation of senescent cells and their inflammatory byproducts leads to the geriatric syndromes of age-related chronic disease and loss of resilience.
A class of medications, known as rapalogs, are known to inhibit TOR, thereby slowing the production of senescent cells which contribute to aging. Rapalogs also simulate the effects of severe caloric restriction, which is known to extend mammalian lifespan, but difficult to achieve in real life. Studies have shown that decreasing TOR leads to improved cardiac function, decreased cancer incidence, improved immune function, and rejuvenation of stem cells. In addition, TOR inhibition metabolizes fat stores and suppresses the accumulation of toxic cellular debris.
At Lowcountry Male, we are one of the few clinics in the country to offer Rapamycin as an exclusive anti- aging treatment for our patients. Rapamycin therapy is the current “gold standard” in longevity medicine and offers the most potential for the extension of healthspan. We follow a protocol based upon the research of Dr Blagosklonny and developed by Dr Alan Green, both respected leaders in the field of Anti-aging. We prescribe low dose rapamycin on a once a week regimen believed to maximize its benefit and minimize potential side effects.
With our Rapamycin protocol, we may see:
• Improved systemic and immune health
• Improved cardiac function and decreased atherosclerosis
• Improved metabolic health, insulin sensitivity, and weight loss
• Decreased inflammation and arthritis
• Improved bone and periodontal health
• May delay cancer
• Possibly delay cognitive decline
• Improved vitality, musculoskeletal preservation, and youthful skin and hair
III. SENOLYTIC THERAPY
While the goal of rapamycin therapy is to decrease the development of senescent cells, senolytic therapy aims to eliminate those cells which have already become senescent and to purge their toxic inflammatory byproducts. Aged and damaged “zombie” cells impede organ function, are pro- inflammatory, and shorten lifespan. These senescent cells produce factors that damage and kill nearby healthy cells, while resisting normal programmed cell death. In animal studies, transplanting a small number of senescent cells into young healthy subjects led to profound physical dysfunction, propagation of more senescent cells, and early death.
A class of medications, known as senolytics, can selectively eliminate these harmful senescent cells but leave healthy cells intact. Additionally, animal studies showed treatment with senolytics increased lifespan by 36%, without increasing the morbidities associated with end of life. In other words, senolytics not only prolong life, but they prolonged healthy life, or lifespan.
Benefits of senolytic therapy include:
• Extension of healthy lifespan
• Improved exercise endurance and decreased frailty
• Improved cardiac and vascular function
• Enhanced appearance of hair and skin
• Decreased osteoporosis and arthritis
• Arrest or reverse age-related neurodegeneration
• Potentially delay onset of cancer thru elimination of damaged and possibly oncogenic cells
Based on a Mayo Clinic protocol, we can offer a prescription only senolytic therapy:
Dasatinib plus quercetin, a 2-week regimen of potent senolytic medications, custom compounded by our pharmacy. This is a potent and clinically proven way to decrease senescent cell burden and its effects last for an extended time period before senescent cells begin to re-accumulate. Patients can repeat this every 6 months to yearly to knock down levels of senescent cell byproducts which have reaccumulated.